 Chronic pain can feel like an endless loop—frustrating, exhausting, and sometimes confusing. If you’re living with persistent pain that doesn’t seem to have a clear physical cause, you’re not alone. Recent research has uncovered that the brain and nervous system play a much bigger role in pain than we once thought. This is called neuroplastic pain, and understanding it can open new doors to recovery.
What is Neuroplastic Pain? Neuroplastic pain refers to pain that arises due to changes in the brain and nervous system, rather than from ongoing tissue injury or disease. The term “neuroplasticity” means that the brain is capable of changing and adapting—sometimes in helpful ways, sometimes in ways that cause problems. When pain becomes chronic, the brain can “learn” pain pathways, making it easier for pain signals to fire even if there is no longer a physical injury. This is similar to how we develop habits: the more we repeat something, the stronger the connection becomes. In neuroplastic pain, the brain’s pain circuits become overactive. How Does Neuroplastic Pain Develop? Neuroplastic pain often begins with an injury, illness, or stressful event. Normally, pain fades as the body heals. But sometimes, pain persists. Factors that can contribute include:
Common Conditions Linked to Neuroplastic Pain Many chronic pain conditions are now understood to have a strong neuroplastic component. These include:
Why Is This Important? Understanding neuroplastic pain can be empowering. It tells us that pain is real—but it’s not necessarily a sign of ongoing injury. The good news is that because the brain learned these pain pathways, it can also “unlearn” them. This opens the door to new treatments that focus on retraining the brain and nervous system. How Can Neuroplastic Pain Be Treated? You might be wondering: “If my pain is coming from my brain, does that mean it’s all in my head?” Absolutely not. Neuroplastic pain is real, and it’s caused by physical changes in the nervous system. The difference is that treatment focuses on the brain and behavior, not just the body. Here are some approaches that have been shown to help: 1. Pain Reprocessing Therapy (PRT) PRT is a new therapeutic approach that helps people reinterpret pain signals as non-dangerous. By changing how you respond to pain, you can help your brain “rewire” and reduce pain over time. A landmark study published in JAMA Psychiatry found that PRT led to significant pain reductions in people with chronic back pain (Ashar et al., 2021). 2. Mindfulness and Meditation Mindfulness helps you observe sensations without judgment or fear. This can calm the nervous system and reduce pain sensitivity. Practices like guided meditation, breathing exercises, and body scans are often used. 3. Education and Cognitive Behavioral Therapy (CBT) Learning about neuroplastic pain can reduce fear and anxiety, which are known to amplify pain. CBT helps you change unhelpful thoughts and behaviors related to pain, making it easier to break the pain cycle. 4. Gradual Movement and Activity Gentle movement, such as walking, stretching, or yoga, can help reassure your brain that your body is safe. Over time, this can decrease pain and increase confidence. What Can You Do Today? If you suspect you have neuroplastic pain, here are some steps you can take:
Chronic pain can be isolating, but you’re not alone. The discovery of neuroplastic pain offers hope to millions of people. By understanding that pain is a product of the brain’s protective mechanisms—and that these mechanisms can be changed—you can take steps toward healing and reclaiming your life. If you’re struggling, reach out for help. Recovery is possible, and every step you take is a victory. Debra is certified in Pain Reprocessing Therapy and can assist you in your healing journey. References
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Debra Eng, MSW, LCSWShe has over 20 years of experience with a wide range of issues. She currently focuses on aging, caregiving, developmental trauma and chronic health and pain conditions. Archives
September 2025
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